Recommendations in this section update and replace recommendations for the early management of unstable angina and NSTEMI from 'Clopidogrel in the treatment of non-ST-segment-elevation acute coronary syndrome', NICE technology appraisal guidance 80 (TA 80). Vranckx P, Valgimigli M, Jüni P, et al. Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial. Lancet 2018; 392:940. Introduction. In the USA, approximately 865000 people will suffer an acute ST-segment elevation myocardial infarction (STEMI) per year (America Heart Association 2006). Detailed Clopidogrel dosage information for adults. Includes dosages for Myocardial Infarction, Ischemic Stroke, Acute Coronary Syndrome and more; plus renal, liver and dialysis adjustments. The current standard of care for patients after an acute coronary syndrome includes dual antiplatelet therapy, typically with aspirin and clopidogrel. 23-27 Despite aggressive use of dual. In patients with ACS (NSTE-ACS or STEMI) treated with DAPT after coronary stent implantation and in patients with NSTE-ACS treated with medical therapy alone (without revascularization), it is reasonable to use ticagrelor in preference to clopidogrel for maintenance P2Y 12 inhibitor therapy (Class IIa). For those who discontinued clopidogrel more than five days before surgery, there was no increased risk of major bleeding within seven days after surgery (4.4% in the clopidogrel arm and 5.3% on placebo). For those who stopped medication within five days of CABG, the rate of major bleeds was 9.6% in the clopidogrel arm and 6.3% on placebo (relative risk 1.53; p=0.06). Overall, the risk of peri. (LTA) in patients with non-ST elevation myocardial infarction (NSTEMI) treated with aspirin and clopidogrel. Methods. Parallel MEA and LTA were performed at baseline and after 6 and 12 weeks in 31. NICE have issued guidance as to the use of antiplatelet agents post myocardial infarction (1): aspirin should be offered to all people after an MI and continue it indefinitely, unless they are aspirin intolerant or have an indication for anticoagulation Medscape - Indication-specific dosing for Plavix (clopidogrel), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.